LymphedemaV1, Main, Exploration, bibRecord, 002372

Treatment of severe or progressive Kaposi's sarcoma in HIV-infected adults

Identifieur interne : 002372 ( Main/Exploration ); précédent : 002371; suivant : 002373

Treatment of severe or progressive Kaposi's sarcoma in HIV-infected adults

Auteurs : Oluwatoyin F. Gbabe [Afrique du Sud] ; Charles I. Okwundu [Afrique du Sud] ; Martin Dedicoat [Royaume-Uni] ; Esther E. Freeman [États-Unis]

Source :

The Cochrane database of systematic reviews [ 1469-493X ] ; 2014.

RBID : PMC:4174344

Abstract

Background

Kaposi's sarcoma remains the most common cancer in Sub-Saharan Africa and the second most common cancer in HIV-infected patients worldwide. Since the introduction of highly active antiretroviral therapy (HAART), there has been a decline in its incidence. However, Kaposi's sarcoma continues to be diagnosed in HIV-infected patients.

Objectives

To assess the added advantage of chemotherapy plusHAART compared toHAART alone; and the advantages of different chemotherapy regimens in HAART and HAART naive HIV infected adults with severe or progressive Kaposi's sarcoma.

Search methods

We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and GATEWAY, the WHO Clinical Trials Registry Platform and the US National Institutes of Health's Clinical Trials.gov for ongoing trials and the Aegis archive of HIV/AIDS for conference abstracts. An updated search was conducted in July 2014.

Selection criteria

Randomised trials and observational studies evaluating the effects of any chemotherapeutic regimen in combination with HAART compared to HAART alone, chemotherapy versus HAART, and comparisons between different chemotherapy regimens.

Data collection and analysis

Two review authors assessed the studies independently and extracted outcome data. We used the risk ratio (RR) with a 95% confidence interval (CI) as the measure of effect. We did not conduct meta-analysis as none of the included trials assessed identical chemotherapy regimens.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174344

PubMed: 25221796
PubMed Central: 4174344

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Kaposi's sarcoma remains the most common cancer in Sub-Saharan Africa and the second most common cancer in HIV-infected patients worldwide. Since the introduction of highly active antiretroviral therapy (HAART), there has been a decline in its incidence. However, Kaposi's sarcoma continues to be diagnosed in HIV-infected patients.</p>
</sec>
<sec id="S2"><title>Objectives</title>
<p id="P2">To assess the added advantage of chemotherapy plusHAART compared toHAART alone; and the advantages of different chemotherapy regimens in HAART and HAART naive HIV infected adults with severe or progressive Kaposi's sarcoma.</p>
</sec>
<sec id="S3"><title>Search methods</title>
<p id="P3">We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and GATEWAY, the WHO Clinical Trials Registry Platform and the US National Institutes of Health's Clinical Trials.gov for ongoing trials and the Aegis archive of HIV/AIDS for conference abstracts. An updated search was conducted in July 2014.</p>
</sec>
<sec id="S4"><title>Selection criteria</title>
<p id="P4">Randomised trials and observational studies evaluating the effects of any chemotherapeutic regimen in combination with HAART compared to HAART alone, chemotherapy versus HAART, and comparisons between different chemotherapy regimens.</p>
</sec>
<sec id="S5"><title>Data collection and analysis</title>
<p id="P5">Two review authors assessed the studies independently and extracted outcome data. We used the risk ratio (RR) with a 95% confidence interval (CI) as the measure of effect. We did not conduct meta-analysis as none of the included trials assessed identical chemotherapy regimens.</p>
</sec>
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</front>
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<name sortKey="Okwundu, Charles I" sort="Okwundu, Charles I" uniqKey="Okwundu C" first="Charles I" last="Okwundu">Charles I. Okwundu</name>
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Treatment of severe or progressive Kaposi's sarcoma in HIV-infected adults

Treatment of severe or progressive Kaposi's sarcoma in HIV-infected adults

Source :

Abstract

Links toward previous steps (curation, corpus...)

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	Serveur d'exploration sur le lymphœdème
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